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Thread on testing & treatment research for COVID-19

Clearly can't stay locked down till 2021 or 2022 when vaccines will (hopefully) be ready.

So ... how about the South Korea plan -- old fashioned public health blocking and tackling. Masks, testing, contact tracing and early treatment with the best-bet medicines that can be given to millions of people. No more "no treatment, sorry" until people are dying in the hospital.

It's not impossible for a large country to do this -- S. Korea is 51 million. How can that country be THAT much more advanced than the US is? When I was growing up, S. Korea was mostly peasants.

BTW S. Korea's new cases yesterday dipped below 20. Not 20 thousand, 20.
For 40 plus years we outsourced our manufacturing base and supply chain to other countries. It’s not that our government doesn’t want to test or build more ventilators but it logistically is impossible to do it overnight based on what has transpired for decades. Things are ramping up and will improve significantly over the next several months but you can’t just crap out 330 million tests or 140,000 ventilators in a couple of months. That doesn’t even take into account the bureaucratic barriers.
 
PA is unusual in having a relatively low testing rate and what also appears to be a lower CFR. Of course, fatalities always lag the case confirmations.
I have been watching Sweden on the Worldometer. They are a strange case. Despite their watered - down measures to create social distance, their rate of new cases has been flat and now appears to be decreasing. They do appear to have a high death rate, though. Their testing rates are actually significantly better than the US right now. I’m not sure that what they are doing would work the same way in the US, but when I see pictures of crowded streets and restaurants in their cities, it does make me wonder.

My theory/guess on Sweden is that they are going beyond what their government is mandating, they are simply doing a better job of self social distancing because it's easier for them to do so. Fifty percent of swedes live alone, they are working from home and they are an older population in general and their older population is already more separated than most (i.e. grand parents don't tend to live with family). They don't go out to eat/drink like we do, there could be other influences on social distancing like mobility and weather. Most of all they are trusting compliant Scandinavians who trust their government and have a huge safety net.

(ps... I have family in Sweden, so this is an informed theory/guess)
 
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Clearly can't stay locked down till 2021 or 2022 when vaccines will (hopefully) be ready.

So ... how about the South Korea plan -- old fashioned public health blocking and tackling. Masks, testing, contact tracing and early treatment with the best-bet medicines that can be given to millions of people. No more "no treatment, sorry" until people are dying in the hospital.

It's not impossible for a large country to do this -- S. Korea is 51 million. How can that country be THAT much more advanced than the US is? When I was growing up, S. Korea was mostly peasants.

BTW S. Korea's new cases yesterday dipped below 20. Not 20 thousand, 20.

Advance planning. Signs were there for anyone to see. South Koreans took them seriously. Helped that the 2015 MERS outbreak gave them an immediate wake-up call. Not sure that something of similar scale in the US would have caused leaders here to pay attention.
 
Saw that data of homeless people at a Boston shelter. Almost 400 tested, 37% positive and none of them at the time had symptoms.
Unless this virus really diminishes in the summer, it looks like by the time a vaccination appears, not many will benefit.
 
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Interesting article with stats based on how different countries attacked the problem (total lockdown; partial lockdown, late installed lockdowns, no lockdowns). Their conclusion is that it didn't matter at all. Just an interesting read and an excerpt to the article

Thanks for posting this Tom.

Analysis

Given the data, it is imperative to elaborate on what caused the decline in the number of new infections.

Some may claim that the decline in the number of additional patients every day is a result of the tight lockdown imposed by the government and health authorities. Examining the data of different countries around the world casts a heavy question mark on the above statement.

It turns out that a similar pattern – rapid increase in infections that reaches a peak in the sixth week and declines from the eighth week – is common to all countries in which the disease was discovered, regardless of their response policies: some imposed a severe and immediate lockdown that included not only “social distancing” and banning crowding, but also
shutout of economy (like Israel); some “ignored” the infection and continued almost a normal life (such as Taiwan, Korea or Sweden), and some initially adopted a lenient policy but soon reversed to a complete lockdown (such as Italy or the State of New York). Nonetheless, the data
shows similar time constants amongst all these countries in regard to the initial rapid growth and the decline of the disease.

For example, our calculations show that the pattern of the daily new infections as a percentage of accumulated number of infections (weekly averaged), is common to every country around the globe. Typically, in the first phase of the spread, this percentage amounted around 30%, decreased to a level of less than 10% after 6 weeks, and ultimately reached a level of less than 5% a week later.
 
SIAP.... looks like another small piece of the Remdesivir study is out.

Early peek at data on Gilead coronavirus drug suggests patients are responding to treatment


"The University of Chicago Medicine recruited 125 people with Covid-19 into Gilead’s two Phase 3 clinical trials. Of those people, 113 had severe disease. All the patients have been treated with daily infusions of remdesivir.

“The best news is that most of our patients have already been discharged, which is great. We’ve only had two patients perish,” said Kathleen Mullane, the University of Chicago infectious disease specialist overseeing the remdesivir studies for the hospital."

https://www.statnews.com/2020/04/16...uggests-patients-are-responding-to-treatment/
 
the results of the study said 5% of the sample had antibodies. That translates into many more exposures than PCR confirmed, symptomatic cases. At the time this study was done, there were 965 PCR confirmed cases in Santa Clara. The antibody testing suggests there were between 46,000 and 87,000 actual cases in same area, but that is a projection they only sampled 3000. The population of Santa Clara county is 1.9 million. But if 5% is the exposure rate we are no where near herd immunity. Herd immunity happens in the 75% exposure range, not the 5% range. 5% exposure rate also means 95% vulnerable rate. So there are still 1.8 million people in Santa Clara who have not had the virus. Sorry that is not good news and does not put us closer to opening. Wish that it did. This dispels the idea virus circulating Cali since November 2019 and there is like 25-50% antibody positive. These results say 5%. Alas, the numbers are what the numbers are, wishing them otherwise s not really helpful......
5% is closer to 75% than 1%. So that is a good thing.

Also, the fact that there are more asymptomatic (or cases with mild symptoms) than previous thought is also good (it means its far more likely that if you get it, you will be fine).

Neither of these things means this isn't serious or that we should relax social distancing. But to present those data as bad news is disingenuous.
 
from the study author:
Bendavid said the research, which has not yet been peer-reviewed, suggests that the large majority of the county, around 95%, is still without antibodies and for getting people back to work “what that means for things like, are we going to wait for people to get infected or get antibodies in order for them to get back to work... knowing that well upwards of 90% of the population doesn't have antibodies is going to make that a very difficult choice."
Right but MORE people (not less) than previously thought have antibodies. That is a good thing.
 
5% is closer to 75% than 1%. So that is a good thing.

Also, the fact that there are more asymptomatic (or cases with mild symptoms) than previous thought is also good (it means its far more likely that if you get it, you will be fine).

Neither of these things means this isn't serious or that we should relax social distancing. But to present those data as bad news is disingenuous.

So with more people having the antibodies, does that mean it's more contagious than we thought or, has it been around longer than we thought? If it was around longer, were there people that may have died from it but were thought to have died from something else?
 
So with more people having the antibodies, does that mean it's more contagious than we thought or, has it been around longer than we thought? If it was around longer, were there people that may have died from it but were thought to have died from something else?
The genetics suggest that it hasn't been around much longer than we thought.

What these data show (to me) is that it is very contagious (which I think we already knew) but that there are lots of people who have had it who were either completely asymptomatic (which doesn't help with contagion) or had very mild symptoms that did not require treatment.

It also speaks to the need for more testing so we have better data.
 
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and then there are the quack preventatives. smh

Lady from Arizona, seen breaking into the Phoenix zoo's even-toed ungulate section. Screaming something about "I've seen it on the Internet!!"

Serious question. Does it make a difference if it is a Dromedary or Bactrian camel? I have access to Dromedary's but Bactrian's are quite rare in my area.

:confused:
 
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It depends on if you prefer one lump or two...sweetener of course.

Lady from Arizona, seen breaking into the Phoenix zoo's even-toed ungulate section. Screaming something about "I've seen it on the Internet!!"

Serious question. Does it make a difference if it is a Dromedary or Bactrian camel? I have access to Dromedary's but Bactrian's are quite rare in my area.

:confused:
 
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