KCLion...Study: Artificial sweetener may treat aggressive cancers

[T J]

Study: Artificial sweetener may treat aggressive cancers

Mar. 23, 2015 - 3:27 - Dr. Ernest Patti explains


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More research is needed and the form and administration may need to be precisely followed.

But, better to get information out to health care practitioners, so that enhanced therapies may someday be possible for difficult cases.

Study: Artificial sweetener may treat aggressive c

 

[Ten Thousan Marbles]

Breaking: Teej adds a name to the short list of scientists he believes.....


Said scientist is doing charity work here (not industry funded) no doubt.

 

[lionlurker]

Reputable medical researchers, as a rule, don't use Fox News

as their main avenue for the release of their data.

 

[T J]

Next up: Ten Thousan Marbles dances on the graves of THON children?



Cancer is an awful disease.

If some individuals with severe cancers can be helped by new advancements, aren't you just an ahole for trying to mock and block the transfer of information that may be helpful in difficult cancer cases.
[/B]
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There are lots of studies that don't pan out over time. Some do.

This particular review cites a specific mechanism that is only in cancer cells, that is being impacted, via cause and effect. If so, then it may have the potential to be a building block for future therapies. If only the cancer cells are impacted, they cited the potential for a pill targeting the cancer cells via this mechanism.

It may not become an avenue for treatment, but some of these kinds of breakthroughs become building blocks upon which further treatments can be based.

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Here's hoping THON continues to fund research into Cancer mechanisms and potential treatments, no matter how many "galactically stupid" individuals oppose these efforts.


This post was edited on 3/24 4:46 PM by T J

 

[LafayetteBear]

Re: Next up: Ten Thousan Marbles dances on the graves of THON children?

AHA! I KNEW my six Coke Zero's a day habit was somehow good for me.

 

[Obliviax]

Here it is from "Medical News Today"

so there's that.

 

[lionlurker]

Cancer is definitely a bad disease, since you brought it up.

However, most of these cancer cure stories are pure quackery. They give false hope to cancer victims, but more importantly, some cancer patients may delay real treatment by wasting time by trying this nonsense first.

I suspect if your wife or child had cancer, your first choice of treatment would not be to ply them with nutrasweet for 6 months and see how they are doing, before heading to Sloan-Kettering or somewhere similar. And if it is, it shouldn't be.

 

[T J]

Please don't be so stupid. You didn't even see the info, did you?


It's incredible how many illogical people jump to their false fantasy conclusions out of ignorance and perhaps bigotry.

You appear to have been well trained like Pavlov's Dogs to respond to Trigger Words, by your political puppet-masters.

Why not try a rational adult response instead, when it comes to complex issues and potential breakthroughs?

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If you had an ounce of common sense... even if you have no background in science... you could have at a minimum, looked at the information, before spouting off with bigoted attacks, childish fantasies and anti-science lunacy.

Here's some information from a review linked in this thread:

Carbonic anhydrase IX regulates the pH of cancer cells and their surroundings, maintaining levels of acidity that are optimum for the growth and spread of cancer to other parts of the body.

As carbonic anhydrase IX[/B] is not typically found in most healthy human cells,

McKenna states that it is a prime target for anticancer drugs.[/B]
Saccharin inhibits carbonic anhydrase IX but not other vital proteins

Unfortunately, carbonic anhydrase IX is similar to other proteins in the body - other forms of carbonic anhydrase that are required for the healthy functioning of the body. The problem researchers faced was how to develop a substance to block carbonic anhydrase IX that did not affect similar proteins needed by the body.

A group of scientists from the University of Florence, Italy, discovered a potential solution to this problem. They found that saccharin inhibits carbonic anhydrase IX but does not affect the other similar proteins that are required to keep the body healthy.
[/B]
Another team from Griffith University, Australia, took this work further by creating a compound in which a glucose molecule is chemically linked to saccharin.

The compound reduced the amount of saccharin needed to inhibit carbonic anhydrase IX and was 1,000 times more likely to bind to the protein than saccharin alone.[/B]

 

[T J]

Since you've already Leaped before you Looked, it's too late for you... yet

Originally posted by Ten Thousan Marbles:

Said scientist is doing charity work here (not industry funded) no doubt.

Below is the reported information regarding funding.

Ten Thousan Marbles demonstrates that there is "no doubt" about his ignorance and his preference for jumping to false conclusions.

Meanwhile, back in reality... the funding information is included in the Release information:

The researchers acknowledge funding by the National Institutes of Health[/B], the European Union[/B] and the Australian Research Council[/B]. The manufacturers of Sweet 'N Low® state that they did not fund this research.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress.[/B]

 

[psufan9808]

Reputable posters, as a rule, don't turn normal threads into political fits


But liberals are generally ruled by emotion so I suppose it is understandable

 

[BUFFALO LION]

Originally posted by T J:
Study: Artificial sweetener may treat aggressive cancers

Mar. 23, 2015 - 3:27 - Dr. Ernest Patti explains


============

More research is needed and the form and administration may need to be precisely followed.

But, better to get information out to health care practitioners, so that enhanced therapies may someday be possible for difficult cases.

Do you have a better link TJ? I'm having trouble finding it on there.

 

[BUFFALO LION]

Re: Reputable medical researchers, as a rule, don't use Fox News

Originally posted by lionlurker:
Reputable medical researchers, as a rule, don't use Fox News[/URL] as their main avenue for the release of their data.

Are you some kind of brain dead idiot? Do you only believe what you watch on MSNBC? It's a big world out there and there are multiple News outlets. Watch them all and get all sides. You'll be far more informed. Who the heck cares if cancer news is coming from the left or right? Any news when it comes to cancer is good news.

By the way. You can read Obli's link if that media spin is acceptable to you.

 

[Ten Thousan Marbles]

from their disclaimer...


Pretty standard stuff, sure. But needs to be said:

"MediLexicon (formerly Pharma-Lexicon) contains links and forms that link to external web sites. In no event shall MediLexicon International Ltd. be responsible for the content, accuracy or opinions expressed in these web sites. These web sites are not monitored or checked for accuracy or completeness by us. Inclusion of web sites linked to via forms and links in our site does not imply approval or endorsement of the linked web site by us. If you decide to leave our web site and access these third-party sites, you do so at your own risk. "

http://www.medilexicon.com/index.php?page=disclaimer&title=Disclaimer

 

[Ten Thousan Marbles]

Doubtless.....you likely believe that....


....that my post was more offensive than yours.

But, you posted that. Still time to walk that back enough so that most won't see it.

 

[belizediver]

Re: Next up: Ten Thousan Marbles dances on the graves of THON children?

Coke Zero and most diet drinks use Nutrisweet (aspartame) and not saccharin.

 

[belizediver]

Re: Cancer is definitely a bad disease, since you brought it up.

Nutrasweet is aspartame, not saccharin by the way.

 

[lionroar88]

What a boneheaded response... just because you don't like TJ doesn't


mean you should laugh this off.

The research indicates that saccharin can reduce the growth rate of some forms of very aggressive cancers (breast, pancreatic, prostate, etc) which can then be treated with other types of treatments (radiation, chemo, etc).

 

[T J]

Try these BUFFALO LION...


Originally posted by BUFFALO LION:

Do you have a better link TJ? I'm having trouble finding it on there.
[/QUOTE]Here is the link to a News discussion about the subject, by a network physician making comments.

https://video.foxnews.com/v/4129589920001/study-artificial-sweetener-may-treat-aggressive-cancers/?playlist_id=930909749001#sp=show-clips


==========

Here is a link to the text version, from their release, that you may find interesting BUFFALO LION:

Popular Artificial Sweetener Could Lead to New Treatments for Aggressive Cancers

See the full release at the link...



http://www.newswise.com/articles/popular-artificial-sweetener-could-lead-to-new-treatments-for-aggressive-cancers

CONTACT:
Robert McKenna, Ph.D.
University of Florida
Department of Biochemistry and Molecular Biology
College of Medicine
Gainesville, FL 32610
Phone: 352-392-5696
Email: rmckenna@ufl.edu

Title
Saccharin and its carbohydrate-conjugate shows promise for isoform selective inhibition of Carbonic Anhydrase IX: a lead approach to anti-cancer drug development

Abstract
Carbonic anhydrase IX (CA IX) is a zinc metalloenzyme that is highly expressed in several aggressive cancer types and its expression has been linked to a poorer prognosis in patients. Inhibition of CA IX has shown to be advantageous in terms of reducing tumor cell proliferation, growth, and inducing chemo- and radiosensitivity in solid tumors. As such, CA IX has been characterized as an ideal anti-cancer target due to its minimal expression in normal human tissue and its physiochemical properties. Despite inhibition of CA IX showing great therapeutic promise, designing selective CA IX inhibitors has been challenging due to its high homology with other ubiquitously expressed human isoforms. Here we demonstrate that saccharin, the main additive in "Sweet N' Low", can be used as a lead compound for structure-based drug design of CA IX selective inhibitors. Furthermore we show how the linkage of a carbohydrate fragment to saccharin enhances CA IX inhibition by >1000-fold over other isoforms and provide insights into the structure-activity relationships of such compounds. This data presents a new class of CA IX inhibitors that will potentially aide in the treatment of several cancers.

This post was edited on 3/24 8:59 PM by T J

 

[lionlurker]

Nah, actually not. I have quite a bit of experience reviewing medical

research, so I really do know what I am talking about. And this stuff is crap.

Don't believe me? Let's plan to meet here in a few years and see who is right.

But by all means, keep getting your medical advice from Fox News, if you like. Plenty of brain-dead idiots probably do.

 

[71camaro]

Re: Nah, actually not. I have quite a bit of experience reviewing medical

Originally posted by lionlurker:
research, so I really do know what I am talking about. And this stuff is crap.

Don't believe me? Let's plan to meet here in a few years and see who is right.

But by all means, keep getting your medical advice from Fox News, if you like. Plenty of brain-dead idiots probably do.

http://biochem.med.ufl.edu/faculty/primary-faculty/robert-mckenna/

From his UF bio:

"Professor Robert McKenna received his Ph.D. in crystallography at the University of London in 1989 under the direction of Professor Stephen Neidle for work on structural studies of nucleic-acid-targeted anti-cancer drug design."

"Current studies include: Carbonic anhydrases, manganese superoxide dismutase, HIV-protease, malaria-plasmepsins, the cancer-associated Mycoplasma hyorhinis protein Mh-p37."

Maybe it isn't complete crap after all?

This post was edited on 3/24 11:46 PM by 71camaro

 

[71camaro]

Re: Nah, actually not. I have quite a bit of experience reviewing medical

Pg. 117 of the ACS conference program, as well

http://www.acs.org/content/dam/acsorg/meetings/spring-2015/acs-denver-onsite-program.pdf


Maybe the guy is presenting his preliminary research while preparing his peer-reviewed work? Just a thought...

 

[CDW3333]

The is all part of TJ schtick, that liberal pseudo-science is always wrong.

Hence, there is no global warming (natch), the Pinto is a safe automobile, and saccharin doesn't cause cancer, it prevents cancer.

Tomorrow, we'll learn how you too can improve your life through regular inhalation of asbestos.

 

[T J]

Such a narrow-minded and boneheaded responses. But, that's your schtick CDW


It's a brand new report and it was offered to a fellow board member, because of some serious problems.

The reported information has plenty of caveats. More research is necessary. The review specifically said that they don't recommend going out and using a particular product. They hope to use this known pathway to exploit a weakness against some very bad cancers, perhaps by linking additional chemo-type treatments that can enter at the same time.

History is full of surprises.

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Narrow-minded and bigoted CDW333...

Please don't EVER use any antibiotics, because "everybody knows," nothing good can come from nasty old "bread mold."[/B]
Yet, that's where an enormous medical breakthrough came from, which has vastly helped mankind.


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We know that many such studies don't pan out over time. But, who knows? ... IF this research area has merit, perhaps additional research institutes will pick up on it, like Griffith University in Australia. They found a way to alter the base product and increase it's binding to the target protein by 1,000 fold.

Perhaps in time, they will be able to use human trials in some fashion... although that looks to be years away, even if things continue to go well.

Perhaps someday, THON funds will be used to enhance this branch of investigation and some children will be helped, as an attack against disease they didn't ask for, that they desperately want to discard from their lives. [/B]